Ccnd1 ELISA Kit for Mouse(Mus musculus) | EIAab.comCcnd1 ELISA Kit for Mouse(Mus musculus)

Search Protein-oriented Product center.

For antibodies, ELISA/CLIA, proteins... Product center

Tips

Index > Protein center > Ccnd1(Gene name) > Mouse

Ccnd1 (Gene name),

G1/S-specific cyclin-D1 (Protein name ), CCND1_MOUSE from NCBI database.

top

General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

Feedback

Gene name:

Ccnd1(Cyl-1);

Protein name:

G1/S-specific cyclin-D1;

Alternative:

Organism:

Mouse (Mus musculus).

General Annotation

Sub Unit:

Interacts with USP2 (By similarity). Interacts with either CDK4 or CDK6 protein kinase to form a serine/threonine kinase holoenzyme complex. The cyclin subunit imparts substrate specificity to the complex. Component of the ternary complex cyclin D/CDK4/CDKN1B required for nuclear translocation and modulation of CDK4-mediated kinase activity. Interacts directly with CDKN1B. Can form similar complexes with either CDKN1A or CDKN2A. Interacts with FBXO4.

Function:

Regulatory component of the cyclin D1-CDK4 (DC) complex that phosphorylates and inhibits members of the retinoblastoma (RB) protein family including RB1 and regulates the cell-cycle during G(1)/S transition. Phosphorylation of RB1 allows dissociation of the transcription factor E2F from the RB/E2F complex and the subsequent transcription of E2F target genes which are responsible for the progression through the G(1) phase. Hypophosphorylates RB1 in early G(1) phase. Cyclin D-CDK4 complexes are major integrators of various mitogenenic and antimitogenic signals. Also substrate for SMAD3, phosphorylating SMAD3 in a cell-cycle-dependent manner and repressing its transcriptional activity. Component of the ternary complex, cyclin D1/CDK4/CDKN1B, required for nuclear translocation and activity of the cyclin D-CDK4 complex.

Subcellular Location:

Nucleus Cytoplasm Membrane Cyclin D-CDK4 complexes accumulate at the nuclear membrane and are then translocated into the nucleus through interaction with KIP/CIP family members.

Protein Attributes:

Sequence length:

295

Sequence:

50:

100:

150:

200:

250:

295:

IEALLESSLR | QAQQNVDPKA | TEEEGEVEEE | AGLACTPTDV | RDVDI

3D Structure:

N/A

Predicted Eptitope:

Please Sign in.

Vaild Sequence:

Please Sign in.

Related Databases

UniGene:

Mm.273049

String:

P25322

SMR:

P25322

Pfam:

PF02984

KEGG:

mmu:12443

Uniprot:

P25322

FOR

ELISA Kit for Mouse G1/S-specific cyclin-D1

Cat.:

E0585h

Price:

Please sign in first.

Manual:

Looking for manual.

MSDS:

Please sign in first.

Packing:

96T

Range:

Please sign in first.

ELISA Kit for Mouse G1/S-specific cyclin-D1

Cat.:

E0585m

Price:

Please sign in first.

Manual:

Looking for manual.

MSDS:

Please sign in first.

Packing:

96T

Range:

Please sign in first.

ELISA Kit for Mouse G1/S-specific cyclin-D1

Cat.:

E0585r

Price:

Please sign in first.

Manual:

Looking for manual.

MSDS:

Please sign in first.

Packing:

96T

Range:

Please sign in first.

ELISA Kit for Mouse G1/S-specific cyclin-D1

Cat.:

E0585b

Price:

Please sign in first.

Manual:

Looking for manual.

MSDS:

Please sign in first.

Packing:

96T

Range:

Please sign in first.

ELISA Kit for Mouse G1/S-specific cyclin-D1

Cat.:

E0585d

Price:

Please sign in first.

MSDS:

Please sign in first.

Packing:

96T

ELISA Kit for Mouse G1/S-specific cyclin-D1

Cat.:

E0585c

Price:

Please sign in first.

MSDS:

Please sign in first.

Packing:

96T

CLIA Kit for Mouse G1/S-specific cyclin-D1

Cat.:

U0585b

Price:

Please sign in first.

MSDS:

Please sign in first.

Packing:

96T

CLIA Kit for Mouse G1/S-specific cyclin-D1

Cat.:

U0585c

Price:

Please sign in first.

MSDS:

Please sign in first.

Packing:

96T

CLIA Kit for Mouse G1/S-specific cyclin-D1

Cat.:

U0585h

Price:

Please sign in first.

MSDS:

Please sign in first.

Packing:

96T

CLIA Kit for Mouse G1/S-specific cyclin-D1

Cat.:

U0585m

Price:

Please sign in first.

MSDS:

Please sign in first.

Packing:

96T

CLIA Kit for Mouse G1/S-specific cyclin-D1

Cat.:

U0585d

Price:

Please sign in first.

MSDS:

Please sign in first.

Packing:

96T

CLIA Kit for Mouse G1/S-specific cyclin-D1

Cat.:

U0585r

Price:

Please sign in first.

Manual:

Looking for manual.

MSDS:

Please sign in first.

Packing:

96T

Range:

Please sign in first.

Polyclonal Antibody for Mouse G1/S-specific cyclin-D1

Cat.:

P0585Rb-m

Price:

Please sign in first.

Packing:

40ug/0.2ml

Polyclonal Antibody for Mouse G1/S-specific cyclin-D1

Cat.:

P0585Rb-h

Price:

Please sign in first.

Packing:

40ug/0.2ml

Polyclonal Antibody for Mouse G1/S-specific cyclin-D1

Cat.:

P0585Rb-r

Price:

Please sign in first.

Packing:

40ug/0.2ml

Polyclonal Antibody for Mouse G1/S-specific cyclin-D1

Monoclonal Antibody for Mouse G1/S-specific cyclin-D1

Protein for Mouse G1/S-specific cyclin-D1

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Recovery

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Linearity

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

References

1.

"Colony-stimulating factor 1 regulates novel cyclins during the G1 phase of the cell cycle."
Matsushime H. , Roussel M.F. , Ashmun R.A. , Sherr C.J.
Cell65:701-713(1991) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
2.

"Genomic organization of the mouse cyclin D1 gene (Cyl-1)."
Smith R. , Peters G. , Dickson C.
Genomics25:85-92(1995) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
3.

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
strain: 129.
tissue: Mammary gland.
4.

"Redistribution of the CDK inhibitor p27 between different cyclin.CDK complexes in the mouse fibroblast cell cycle and in cells arrested with lovastatin or ultraviolet irradiation."
Poon R.Y. , Toyoshima H. , Hunter T.
Mol. Biol. Cell6:1197-1213(1995) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH CDKN1B IN THE CCND1-CDK4-CDKN1B COMPLEX
5.

"Phosphorylation-dependent ubiquitination of cyclin D1 by the SCF(FBX4-alphaB crystallin) complex."
Lin D.I. , Barbash O. , Kumar K.G. , Weber J.D. , Harper J.W. , Klein-Szanto A.J. , Rustgi A. , Fuchs S.Y. , Diehl J.A.
Mol. Cell24:355-366(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: UBIQUITINATION;INTERACTION WITH FBXO4;INTERACTION WITH A UBIQUITIN LIGASE COMPLEX CONTAINING CRYAB;SKP1;CUL1 AND FBXO4;MUTAGENESIS OF THR-286;PHOSPHORYLATION AT THR-286
6.

"Lysine 269 is essential for cyclin D1 ubiquitylation by the SCF(Fbx4/alphaB-crystallin) ligase and subsequent proteasome-dependent degradation."
Barbash O. , Egan E. , Pontano L.L. , Kosak J. , Diehl J.A.
Oncogene28:4317-4325(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: UBIQUITINATION AT LYS-269;INTERACTION WITH CDKN1B AND CDK4;SUBUNIT;SUBCELLULAR LOCATION;MUTAGENESIS OF LYS-269 AND THR-286

Product Feedback Wall

* Email:
*Comments: